Unlocking Polymers in Medical Devices - Combining High Resolution Separations from the Waters ACQUITY APC and Advanced Detectors

Live webinar November 2nd 2021

In recent years, new developments in Size Exclusion Chromatography (SEC) have resulted in the introduction of Ultra-High-Performance Liquid Chromatography (UHPLC or UPLC®) for polymer applications. Waters ACQUITY Advanced Polymer Chromatography (APC™) is a breakthrough technology that provides SEC analyses of polymeric materials with higher resolution and higher speed than conventional SEC. The new APC technology involves the use of high efficiency separation columns and a low dispersion flow path, resulting in:

High-resolution analysis

Reduced time

Reduced solvent consumption

Reduced sample concentration

Quick mobile phase changeover

Traditionally, the APC system has focused on conventional calibration, meaning it can only generate relative molecular weight information. To obtain comprehensive knowledge of the polymers under analysis, it is necessary to combine the high-resolution APC system with additional advanced detectors. The combination of the Waters APC system with the Malvern Panalytical OMNISEC REVEAL, containing refractive index (RI), UV-Vis photodiode array (UV), light scattering (LS), and differential viscometry detectors, greatly broadens the information attainable from a SEC analysis. Using OMNISEC REVEAL the sample under analysis can now be fully characterized in terms of:

Absolute molecular weight: without the need for column calibration

Molecular weight distribution

Size: hydrodynamic radius across the sample’s entire molecular weight range

Structure: Mark-Houwink parameters

Composition

This presentation will discuss the characterization of block copolymers among others commonly used in medical devices by a Waters ACQUITY APC combined with the Malvern Panalytical OMNISEC REVEAL multi-detector system.

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