Revolutionizing Purification: RotaChrom's Continuous CPC Platform

Innovation in Continuous Manufacturing

In the pursuit of enhanced efficiency, cost-effectiveness, and sustainability in industrial processes, the arrival of Continuous Centrifugal Partition Chromatography (CPC) marks a significant advancement. RotaChrom’s innovative purification platform promises to redefine traditional purification techniques and offer a variety of advantages for businesses in the pharmaceutical, natural extract, agrochemical, and many other fields.

CPC, a technique rooted in liquid-liquid preparative chromatography principles, operates through the interaction of two immiscible liquid solvent systems. These systems, serving as both stationary and mobile phases, allow chromatographic separations to take place without using any solid stationary phase. Central to CPC's functionality is the partition coefficient (Kd), governing the equilibrium distribution of compounds between the phases.

How It Works

CPC devices use a series of interconnected cells (or columns), attached to a large rotor. Once the rotor starts spinning, a strong centrifugal force immobilizes the liquid stationary phase, while the mobile phase, containing the sample for purification, is injected into the system in the form of tiny droplets.

What distinguishes CPC is its adaptability, particularly showcased through dual-mode chromatography—a method that switches the roles and flow directions of liquid phases. This innovative technique extends column length effectively, thereby enhancing the system's resolving power.

At the forefront of this transformative technology is RotaChrom, with its Continuous CPC platform. The platform involves two interconnected CPC devices, a preparative unit with industrial valves and pumps, and a control unit serving as the platform's core. The Continuous CPC platform is engineered for scalability and adaptability. Meeting strict industrial standards, it embodies robustness and durability, ensuring seamless integration into diverse production environments.

Advantages of Continuous Purification

The Continuous CPC platform boasts not only versatility but also exceptional efficiency. Equipped with an on-demand solvent handling system tailored to industrial standards, it optimizes purification processes. Its continuous injection mode further augments throughput, facilitating rapid sample processing.

RotaChrom spares no effort in ensuring compliance with rigorous standards. The device aligns with stringent cleaning validation and GMP directives, underscoring its commitment to industry excellence.

Safety is a priority, as the Continuous CPC is explosion-proof, suitable for installation in rooms classified as ATEX/IECEx Zone 2. Additionally, the electrical cabinet comes pre-certified for added safety assurance.

In terms of construction, all wetted components are constructed from high-quality materials like 316L/1.4404 stainless steel or PEEK, known for their resistance to corrosion and chemical reactions.

Learn More About the Platform

To see the Continuous CPC in operation, watch this informative video here: https://www.youtube.com/watch?v=mLGbCP6qd-8.

Experience firsthand how RotaChrom is reshaping production paradigms and pioneering a sustainable future in manufacturing.

Embark on a journey into the realm of Continuous Centrifugal Partition Chromatography with RotaChrom. Watch the video now and unlock the future of continuous purification.