The Role of Sinusoidal Pumps in Enhancing Plasma Protein Processing Efficiency

Sinusoidal pumps, characterized by their unique flow dynamics and low-shear operation, are emerging as critical tools in bioprocessing applications. This article explores their advantages in plasma protein fractionation, purification, and transfer.

Plasma proteins, including albumin, immunoglobulins, and clotting factors, are vital for therapeutic and diagnostic applications. Their extraction from blood plasma demands gentle handling to preserve structural integrity and biological activity. Traditional peristaltic or centrifugal pumps often introduce shear stress and pulsation, risking protein denaturation. Sinusoidal pumps address these challenges through biomimetic flow patterns, making them ideal for sensitive biologics.

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Applications in Plasma Protein Processing

.1 Fractionation & Purification In cold ethanol fractionation, sinusoidal pumps ensure: Stable flow rates during sequential precipitation steps, improving yield of IgG (up to 92% recovery reported). Reduced turbulence during albumin filtration, minimizing subvisible particle formation. 2 Sterile Filling For final container filling (e.g., 20% albumin solutions): CIP/SIP compatibility meets GMP requirements for sterile biologics. Flow pauses <0.1 sec prevent droplet formation, maintaining vial sterility. 3 Scalability Case study: A European plasma manufacturer achieved: 30% faster processing time vs. lobe pumps in 5,000L scale production. 15% reduction in protein aggregates in final QC assays.

Challenges & Solutions

Viscosity Sensitivity: Adaptive pressure sensors adjust motor torque for high-viscosity cryoprecipitate transfers. Material Compatibility: FDA-grade PTFE diaphragms prevent leachables in pH 4–9 processing buffers.

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Sha Cheng Jie, Long Wan Qu, Wen Zhou Shi, Zhe Jiang Sheng, China

ZHEJIANG XINGSHENG MACHINERY CO.,LTD

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