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Homogeneous Grinding of Cannabis – Efficient Extraction of the Supercritical CO2

For an efficient extraction of cannabis oil and to receive a homogeneous sample - utilising the Universal Cutting Mill PULVERISETTE 19!

The FRITSCH Cutting Mill PULVERISETTE 19 with variable rotational speed and Cyclone is an efficient instrument to receive both: optimal, homogeneous sample of large quantities of cannabis plants and for CO2 extraction to produce cannabis oils. Have a look how easy cannabis can be prepared.

Supercritical CO2 Extraction

The most common method to extract the active ingredients from the cannabis plant is supercritical CO2 extraction. At above 31°C and with high pressure the CO2 gets into the "supercritical" state. It now acts as a solvent. It is passed through a chamber containing the plant material. The CO2 has still the density of a liquid, but can fill the entire chamber like a gas. This is ideal for extraction as it does not cause denaturation or damage to the product.

The CO2 extracts the cannabinoids and terpenes from the plant. The result is a safe, high-quality, pure oil, which can now be processed for various therapeutic applications.

The producers of these cannabis oils naturally want to make the extraction process as efficient as possible. That means: the highest possible yield of the ingredients in the shortest possible time.

Homogeneous grinding of cannabis

The requirement for this is an optimal, homogeneous grinding of the cannabis plant. The ideal instrument for this is the FRITSCH PULVERISETTE 19 – an Universal Cutting Mill for fine grinding and for precise comminution.

Perfect grinding chamber geometry

In Cutting Mills, the sample is shredded between the knives of the rotor and the counter knives in the grinding chamber using the principle of a pair of scissors to produce the desired final fineness. The unique grinding chamber geometry of the FRITSCH Universal Cutting Mill PULVERISETTE 19 ensures minimal dead space. The progressive cutting geometry between the rotor and stator knives actively transports the sample material. It cannot get stuck anywhere. The special air flow is the basis for quick, clog-free work and quick residue-free cleaning. In addition, the use of the stainless-steel high-performance Cyclone separator ensures high throughput.

With the help of an industrial vacuum cleaner and the high-performance Cyclone separator, a negative pressure is generated in the grinding chamber. The material is fed into the FRITSCH PULVERISETTE 19 via a funnel. Different sieve cassettes define the final fineness of the cannabis sample.

Unmilled cannabis plant material has a bulk density of 100-125 g/litre, while ground material has a bulk density of 225-250 g/litre.

The sample is optimally homogenised by the grinding and significantly more material can be filled into the extraction column. Of course, this also significantly increases the yield per extraction.

In cooperation with a cannabis producer in California, USA, we examined which degree of grinding means the optimum for the most efficient extraction. The best results are achieved with the 2 mm sieve. Other screens can also be used for different fractions.

More PULVERISETTE 19 facts

The FRITSCH Universal Cutting Mill PULVERISETTE 19 is also used to grind samples for the potency testing or to examine the material for pesticide residues. In order to optimally adapt the cutting performance to the sample, the speed of the rotor can be regulated between 300 rpm to 3000 rpm.

As with all mills used in analytical laboratories, simple cleaning is desirable. The concept of the Clean Design was used for the FRITSCH PULVERISETTE 19: the grinding chamber can be opened completely, all grinding parts can be removed without tools for easy and fast cleaning. Cross contamination can be effectively avoided.

The FRITSCH PULVERISETTE 19 is also available in a 316L stainless steel version for use in the pharmaceutical sector.


Send us your most difficult sample – we will carry out an individual sample grinding for you. Compare for yourself!


  • Idar-Oberstein, Germany
  • Aaron Juchem