Analytical method of carbon dioxide and residual oxygen content in pharmaceutical packaging

CO2 and Oxygen content in pharmaceutical packaging

There are many types and forms of pharmaceutical products, most of which are sensitive to oxygen, easily oxidized and deteriorated, discolored, and smelly, etc., which not only affect the curative effect of the product, but the toxic and harmful substances produced by oxidation can even endanger life. Medicines with ingredients such as calcium salts tend to absorb carbon dioxide to form carbonates. In order to reduce the amount of oxygen and carbon dioxide that medicines are exposed to as much as possible, oxygen and carbon dioxide sensitive medicines are usually packaged in the form of vacuuming and filling in inert gases such as nitrogen to reduce the content of oxygen and carbon dioxide in the packaging. However, vacuum packaging and nitrogen-filled packaging cannot completely remove or replace the gas inside the package, and the packaging material has a certain degree of air permeability, so there will always be a certain amount of oxygen and carbon dioxide left in the package, and the content of gas components is not constant. It will increase with the extension of drug storage time. Monitoring the residual oxygen and carbon dioxide content in the packaging is not only one of the effective means to ensure the good quality of drugs, but also a basis for determining the shelf life.