#White Papers
Pharmaceutical Manufacturer Boosts API Microsphere Output by 500% with Aseptic Sieving Solution
Innovative sieving solutions for high‑performance API processing
A leading global pharmaceutical manufacturer has achieved a 500% increase in productivity after upgrading its sterile powder screening process for high‑value microsphere active pharmaceutical ingredients (APIs).
The company—producing over 250 aseptic, high‑purity APIs including peptide‑based medicines—required a more efficient method to sieve microsphere powders between 1–1,000 microns. Its previous ultrasonic sifter was limited to 1.5 kg/hour, creating a bottleneck that restricted the scale‑up of its aseptic manufacturing line.
To resolve this, the manufacturer installed the Russell Compact Sieve® MS400 equipped with a side‑mounted ultrasonic deblinding system, a GMP‑compliant solution designed specifically for sterile powder handling.
After commissioning the new system, the company increased its screening capacity to 10 kg/hour, significantly reducing process interruptions and meeting growing customer demand. Operator handling has been reduced by 30–40%, improving safety and reducing the risk of contamination. Lower autoclaving requirements have also resulted in reduced energy usage, fewer consumables, and better alignment with VHP isolator cleaning protocols.
About Russell Finex
Russell Finex is the only global manufacturer that produces both screening and filtration equipment alongside ultrasonic mesh deblinding systems. With over 90 years of experience across virtually every industry, the company delivers customized solutions that enhance throughput, product quality, and operational efficiency—while maintaining responsible and ethical practices.
Contact Russell Finex today to discover how our sieving technologies can optimize your pharmaceutical powder processing.
